How does this medication work? What will it do for me?
Deferasirox belongs to the class of medications known as iron chelators. It is used to treat the iron overload that occurs when anemia is treated with frequent blood transfusions. It is used in adults and children 6 years and older. It is also used in children 2 to 5 years old for whom deferoxamine is not providing an adequate response. It works by binding to excess iron in the blood and removing it from the body (mainly through the stools), thereby relieving the iron overload caused by blood transfusions. It can also be used to treat chronic iron overload in people 10 years of age and older who have thalassemia and do not require regular blood transfusions.
Deferasirox has been granted a notice of compliance with conditions (NOC/c) by Health Canada. This means that Health Canada has approved this medication to be marketed based on promising evidence of effectiveness, but additional results of studies are needed to verify its effectiveness. An NOC/c is used to allow access to products that are used to treat or prevent serious, life-threatening, or severely debilitating illness. Health Canada has also granted deferasirox a regular NOC (no conditions) for cases where it is used to treat people with thalassemia who do not require regular blood transfusions.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
What form(s) does this medication come in?
Each off-white, round, flat, bevelled-edged, dispersible tablet, imprinted with "J 125" on one side and "NVR" on the other, contains deferasirox 125 mg. Nonmedicinal ingredients: lactose monohydrate, crospovidone, povidone (K30), sodium lauryl sulphate, microcrystalline cellulose, colloidal silicon dioxide, and magnesium stearate.
Each off-white, round, flat, bevelled-edged, dispersible tablet, imprinted with "J 250" on one side and "NVR" on the other, contains deferasirox 250 mg. Nonmedicinal ingredients: lactose monohydrate, crospovidone, povidone (K30), sodium lauryl sulphate, microcrystalline cellulose, colloidal silicon dioxide, and magnesium stearate.
Each off-white, round, flat, bevelled-edged, dispersible tablet, imprinted with "J 500" on one side and "NVR" on the other, contains deferasirox 500 mg. Nonmedicinal ingredients: lactose monohydrate, crospovidone, povidone (K30), sodium lauryl sulphate, microcrystalline cellulose, colloidal silicon dioxide, and magnesium stearate.
How should I use this medication?
The usual recommended starting dose of deferasirox is 10 mg to 30 mg per kilogram of body weight per day, depending on the individual. Your doctor will determine the exact dosage that is appropriate for your circumstances.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Deferasirox should be taken once daily at about the same time each day. It should be taken on an empty stomach and at least 30 minutes before the first meal of the day. The tablets must be mixed with water, apple, or orange juice (100 mL of liquid for doses of less than 1 g, and 200 mL for doses of 1 g or more). Drop the tablet into the liquid and stir until the tablet dissolves completely. Drink all the liquid, then add a little water or juice to what is left in the glass and drink that as well. Do not chew or crush the tablets, or swallow them whole.
Do not use milk or carbonated beverages such as soda pop to dissolve the tablets. Milk slows down dissolution and carbonated beverages will foam up.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children. Leave the medication in its original package until it is time to take a dose.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Who should NOT take this medication?
Do not take this medication if you:
- are allergic to deferasirox or any ingredients of this medication
- have a low platelet count (less than 50 x 109 / L)
- have myelodysplastic syndrome (MDS)
- have rapidly worsening disease and are not likely to be helped with chelation therapy
- have severe kidney impairment (creatinine clearance less than 60 mL per minute)
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- skin rash, redness, or blistering
- stomach pain
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- blurred or cloudy eyesight
- reduced hearing
- signs of gastrointestinal (stomach or intestines) bleeding, such as vomiting blood and/or black stools
- heartburn or abdominal pain (ulcers) particularly after eating or taking the drug
- signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine)
- signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
Stop taking the medication and seek immediate medical attention if any of the following occur:
- chest pain
- signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort
- symptoms of a severe allergic reaction (hives; skin rash; itchy skin; trouble breathing; swelling of the face, lips, tongue, or throat)
- vision loss
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Blood clotting: This medication can reduce the number of platelet cells in the blood. Platelets help the blood to clot and a shortage could make you bleed more easily. Tell your doctor about any signs that your blood is not clotting as quickly as usual. Such symptoms may include black and tarry stools, blood in the urine, easy bruising, or cuts that won't stop bleeding.
Your doctor will do blood tests regularly to monitor the number of specific types of blood cells, including platelets, in your blood.
Dizziness: Deferasirox may cause dizziness. Do not drive, operate machinery, or perform other potentially hazardous tasks until you have determined how this medication affects you.
Hearing problems: Deferasirox may cause hearing problems such as decreased hearing or difficulty hearing high-pitched sounds. Your doctor may recommend you have hearing tests before and throughout treatment. If you notice changes in your hearing, contact your doctor as soon as possible.
Heart failure: This medication is not recommended for people with heart failure due to iron overload. If you have heart failure caused by iron overload, discuss with your doctor how this medication may affect your medical condition, how your medical condition or medications may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Kidney function: Deferasirox may cause serious kidney problems, including kidney failure. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Your doctor may recommend you have your kidney function tested regularly throughout treatment. This can be done with blood tests.
Liver function: This medication is not recommended for people with severe liver impairment. Deferasirox may cause serious liver problems, including liver failure. If you have reduced liver function or liver disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Your doctor may recommend you have your liver function tested regularly throughout treatment. This can be done with blood tests.
Laboratory tests: Your doctor may recommend regular blood tests to monitor your response to this medication, the effect the medication has on your liver and kidney, and to monitor your blood cell levels.
Lactose intolerance: This medication contains lactose. It is not recommended for people with hereditary galactose intolerance, glucose-galactose malabsorption, or severe lactase deficiency.
If you have poor lactose tolerance, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Skin rash: This medication may cause a skin rash. Mild-to-moderate rashes often resolve without treatment and do not require any changes in deferasirox therapy. Severe rashes may require a change in dose, or treatment may need to be stopped, as recommended by your doctor. If you notice symptoms including a rash, itching, blistering or peeling skin, contact your doctor right away.
Stomach problems: Deferasirox can irritate the lining of the stomach and cause indigestion, or in more serious situations, bleeding in the stomach and digestive system. This is more likely to happen when you are also taking other medications that irritate the stomach, such as anti-inflammatory pain relievers (e.g., acetylsalicylic acid or ibuprofen).
If you have stomach problems, have a history of stomach problems, or are taking and mediations that can irritate the stomach, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Vision problems: Changes to your vision or eyes, such as cloudy vision or cataracts, may occur with the use of deferasirox. Your doctor may recommend you have eye tests before and throughout treatment. If you notice changes in your vision, contact your doctor as soon as possible.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if deferasirox passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of this medication have not been established for children less than 2 years of age.
Seniors: Seniors are at an increased risk of experiencing side effects related to the kidneys, liver, and heart. If you are a senior, your doctor should closely monitor your condition while you are taking deferasirox.
What other drugs could interact with this medication?
There may be an interaction between deferasirox and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 2018. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Exjade