How does this medication work? What will it do for me?
This combination product contains 3 medications: codeine, triprolidine, and pseudoephedrine.
Codeine belongs to the group of medications called narcotic analgesics and cough suppressants.
Triprolidine belongs to the group of medications called antihistamines, and helps to relieve sneezing and runny nose.
Pseudoephedrine belongs to the group of medications called nasal decongestants, and reduces nasal congestion.
Codeine - triprolidine - pseudoephedrine is used to treat coughs related to inflamed tissues in the nose and throat. It works by reducing inflammation in the nose and throat tissues and decreasing cough.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
What form(s) does this medication come in?
This medication is available as a syrup. Each 5 mL of syrup contains 10 mg of codeine phosphate, 2 mg of triprolidine HCl, and 30 mg of pseudoephedrine HCl.
How should I use this medication?
Note: A cough is a symptom. Before taking a cough suppressant, it is important to assess the underlying cause of the cough.
The recommended dose for adults is 10 mL (2 teaspoons), every 6 or 8 hours as needed. No more than 4 doses should be taken in a 24-hour period.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Use an oral syringe to measure each dose of the liquid, as it gives a more accurate measurement than household teaspoons.
It is important to take this medication exactly as prescribed by your doctor. If your doctor has told you to take this medication on a regular basis and you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Who should NOT take this medication?
Do not use this medication if you:
- are allergic to codeine, triprolidine, pseudoephedrine, or any of the ingredients of the medication
- are allergic to codeine-like narcotics, other similar antihistamines, or decongestants
- are at risk of respiratory failure
- are breast-feeding
- are known to be an “ultra rapid metabolizer” of codeine (i.e., your body changes codeine to morphine faster than normal)
- are pregnant
- are taking an MAO inhibitor (e.g., phenelzine, tranylcypromine) or have taken one in the past 2 weeks
- are taking certain other medications such as decongestants, appetite suppressants, stimulants, or medications used for the treatment of ADHD (attention-deficit/hyperactivity disorder)
- are under 18 years of age
- have a cough with a significant amount of phlegm or other secretions
- have a head injury or increased pressure inside the brain
- have an ongoing or persistent cough, such as that which occurs with asthma, emphysema or smoking
- have decreased kidney function
- have high blood pressure
- have pheochromocytoma (a type of adrenal gland tumour)
- have reduced liver function
- have respiratory problems, such as chronic obstructive pulmonary disease or asthma
- have severe coronary artery disease
- have ulcerative colitis (inflammation of the digestive tract)
This medication should not be given to newborn or premature infants.
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- difficulty concentrating
- difficulty sleeping
- dry mouth, nose or throat
- feeling bloated
- sensation of spinning
- skin rash
Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- severe constipation
- difficult or painful urination
- hallucinations (seeing or hearing things that aren’t there)
- increased or irregular heart rate
- itchy skin
- signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
- signs of low blood pressure (dizziness, fainting, lightheadedness)
- thickening phlegm
- unusual excitement or restlessness
- vision changes (blurred vision, eye pain)
Stop taking the medication and seek immediate medical attention if any of the following occur:
- signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
- signs of brain injury (e.g., confusion, inability to concentrate, decreased awareness, consciousness)
- signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
- signs of decreased blood flow to the digestive tract (e.g., sudden abdominal pain, rectal bleeding, blood in the stools)
- signs of intolerance to pseudoephedrine (e.g., drowsiness, dizziness, weakness, difficulty breathing, rapid heart rate)
- symptoms of overdose of codeine, such as:
- abnormally slow or weak breathing
- cold, clammy skin
- extreme drowsiness
- severe dizziness
- slow heartbeat
- symptoms of cerebral vasoconstriction syndrome (e.g., sudden severe headache, nausea, vomiting, vision changes)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
HEALTH CANADA ADVISORY
August 24, 2020
Health Canada has issued new restrictions concerning the use of prescription codeine. To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.
Previous advisories on prescription codeine were issued on July 28, 2016 and June 6, 2013.
Abdominal conditions: Codeine, like other narcotic medications, may make the diagnosis of abdominal conditions more difficult or it may worsen these conditions. If you are scheduled for abdominal surgery or have an abdominal condition such as inflammatory or obstructive bowel disease, acute cholecystitis, or pancreatitis, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Breathing: Codeine can suppress breathing. Children are more likely to experience serious breathing problems, including death. For this reason, this medication should not be given to people less than 18 years old. If you are at risk of breathing difficulties, such as asthma, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Constipation: Codeine can be very constipating. Eating a high-fibre diet and following good bowel habits will help to minimize this effect. If you develop constipation easily, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Dependence and withdrawal: This medication contains codeine. Physical dependence, psychological dependence, and abuse have occurred with the use of codeine. People with a history of past or current substance use problems may be at greater risk of developing abuse or addiction while taking this medication. Abuse is not a problem with people who require this medication for pain relief.
If you suddenly stop taking this medication, you may experience withdrawal symptoms such as anxiety, sweating, trouble sleeping, shaking, pain, nausea, tremors, diarrhea, and hallucinations. If you have been taking this medication for a while, it should be stopped gradually as directed by your doctor.
Diabetes: The pseudoephedrine in this medication may cause blood sugar to become less controlled for people with diabetes. This medication also contains sugar, which may increase blood glucose levels. It may become necessary to test your blood glucose levels more often when taking codeine - triprolidine - pseudoephedrine - guaifenesin.
If you have diabetes, or are at risk of developing diabetes, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Drowsiness/reduced alertness: Codeine may cause drowsiness. Do not drive, operate machinery, or perform any potentially hazardous tasks until you know how this medication affects you.
Glaucoma: Codeine - triprolidine - pseudoephedrine may make glaucoma worse. It may also cause glaucoma to develop. If you have narrow-angle glaucoma or are at risk of developing glaucoma, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Head injury: If you have a head injury or increased pressure in the head, you may have a higher risk of experiencing side effects (breathing problems) or worsening of their condition while taking this medication. Discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Heart disease: This medication may make symptoms of certain heart conditions worse. If you have an irregular heart rhythm, ischemic heart disease, high blood pressure or other heart condition, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Kidney disease: If you have kidney disease or reduced kidney function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Liver disease: If you have liver disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Other medical conditions: The medications in codeine - triprolidine - pseudoephedrine can have an effect on other medical conditions. The codeine may make symptoms of delirium tremens or acute alcohol intoxication worse. As well, triprolidine and pseudoephedrine may worsen symptoms of low thyroid (hypothyroidism), Addison's disease, benign prostatic hypertrophy (enlarged prostate), gallbladder disease, urethral stricture, decreased function of the adrenal glands, or porphyria. If you have any of these conditions, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Pregnancy: This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: This medication passes into breast milk. Some of the codeine dose is converted into morphine by the body, once it has been taken. For some people, this change happens much faster than for others. If this happens to a nursing mother, the baby is at risk of receiving a morphine overdose through the breast milk. If you are a breast-feeding mother and are taking codeine - triprolidine - pseudoephedrine, it may affect your baby. Taking this medication while breast-feeding is not recommended.
Children: Codeine - triprolidine - pseudoephedrine should not be given to children less than 18 years of age.
Seniors: This medication is more likely to cause side effects for those 60 years of age and older. Lower doses may be necessary.
What other drugs could interact with this medication?
There may be an interaction between codeine - triprolidine - pseudoephedrine and any of the following:
- alpha blockers (e.g., alfuzosin, doxazosin, tamsulosin)
- amphetamines (e.g., dextroamphetamine, lisdexamphetamine)
- antihistamines (e.g,. cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
- antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
- barbiturates (e.g., phenobarbital, butalbital)
- benzodiazepines (e.g., diazepam, lorazepam, oxazepam)
- chloral hydrate
- diuretics (water pills; e.g., furosemide, hydrochlorothiazide, triamterene)
- ergot alkaloids (e.g., ergotamine, dihydroergotamine)
- general anesthetics (medications used to put people to sleep before surgery)
- certain HIV protease inhibitors (e.g., lopinavir, ritonavir, tipranavir)
- monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, rasagiline, selegiline, phenelzine, tranylcypromine)
- muscle relaxants (e.g., baclofen, cyclobenzaprine, methocarbamol, orphenadrine)
- other narcotic pain relievers (e.g., fentanyl, hydrocodone, morphine)
- potassium chloride
- St. John's wort
- seizure medications (e.g., carbamazepine, clobazam, levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid, zonisamide)
- selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluvoxamine, paroxetine, sertraline)
- serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., desvenlafaxine, duloxetine, venlafaxine)
- tetrahydrocannabinol (THC)
- tricyclic antidepressants (e.g., amitriptyline, desipramine, nortriptyline)
- "triptan" migraine medications (e.g., eletriptan, sumatriptan)
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
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